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Influence of lipid composition on pediocin PA-1 binding to phospholipid vesicles
Y Chen1, R D Ludescher, T J Montville
1Department of Food Science, Cook College, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA.
Applied and Environmental Microbiology
|September 3, 1998
Abstract:
Pediocin PA-1 bound to anionic lipid vesicles with saturated or unsaturated fatty acid chains in a lipid concentration-dependent fashion. Little change in binding parameters was observed for zwitterionic lipid vesicles. Decreasing the anionic lipid content of the vesicles gave a higher relative dissociation constant for the peptide-lipid interactions and further supports the electrostatic interaction model of binding.