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Estimation of apoptosis in C6 glioma cells treated with antidepressants
1Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Brno.
Physiological Research
|January 1, 1997
Abstract:
Gel electrophoresis of DNA was used for estimation of DNA changes caused in C6 glioma cells by treatment with psychotropic drugs (imipramine, amitryptiline and fluoxetine). Some discrete bands containing a population of short DNA fragments appeared after 1 and 5 days of cultivation. Apoptotic DNA breaks were verified at single cell level using the TUNEL test in cells treated with fluoxetine.