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Related Experiment Videos

Evidence for mast cell activation during exercise-induced bronchoconstriction

S O'Sullivan1, A Roquet, B Dahlén

  • 1Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

The European Respiratory Journal
|September 4, 1998
PubMed
Summary

Mast cell activation, indicated by increased urinary 9alpha,11beta-prostaglandin F2, occurs during exercise-induced bronchoconstriction in asthma. This study provides evidence for mast cell involvement in asthmatic responses to exercise.

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Area of Science:

  • Immunology
  • Pulmonology
  • Biochemistry

Background:

  • Exercise-induced bronchoconstriction (EIB) is a common asthma symptom.
  • The precise mediators triggering EIB remain debated.

Purpose of the Study:

  • To investigate mast cell activation during EIB.
  • To measure urinary metabolites of mast cell mediators post-exercise.

Main Methods:

  • Twelve mild asthmatics underwent a 5-minute exercise challenge.
  • Pulmonary function was monitored.
  • Urinary samples were collected pre- and post-exercise (30 and 90 min).
  • Urinary concentrations of 9alpha,11beta-prostaglandin F2, Ntau-methylhistamine, and leukotriene E4 were measured.

Main Results:

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  • Seven subjects (responders) showed >15% fall in FEV1 post-exercise.
  • Responders exhibited significantly higher urinary 9alpha,11beta-prostaglandin F2 levels at 30 and 90 min compared to non-responders.
  • No significant differences in urinary Ntau-methylhistamine or leukotriene E4 were observed.

Conclusions:

  • Increased urinary 9alpha,11beta-prostaglandin F2 confirms mast cell activation in EIB.
  • This study provides the first documentation of elevated 9alpha,11beta-prostaglandin F2 in adults with EIB.
  • Mast cell activation is a key component of exercise-induced bronchoconstriction in asthma.