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Naloxone does not alter the "regulated" decrease in core temperature during hypoxemia in guinea pigs

K C Crisanti1, J E Fewell

  • 1Department of Physiology and Biophysics, The University of Calgary Health Sciences Centre, Calgary, Alberta T2N 4N1, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 8, 1998
PubMed
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Endogenous opioids do not mediate the regulated decrease in core body temperature during hypoxemia in guinea pigs. Naloxone, an opioid antagonist, did not alter temperature responses but affected oxygen consumption.

Area of Science:

  • Physiology
  • Neonatal Physiology
  • Thermoregulation

Background:

  • Acute hypoxemia in newborns and adults causes a regulated decrease in core body temperature.
  • The underlying physiological mechanism for this temperature decrease remains unknown.
  • Endogenous opioids are hypothesized to play a role in this hypoxemia-induced hypothermia.

Purpose of the Study:

  • To investigate the role of endogenous opioids in mediating the regulated decrease in core body temperature during acute hypoxemia.
  • To test the hypothesis that opioid antagonists can block this hypothermic response.

Main Methods:

  • Experiments conducted on chronically instrumented newborn (5-10 days) and older (25-30 days) guinea pigs.
  • Measurements included core temperature, oxygen consumption, and ambient temperature in a thermocline.

Related Experiment Videos

  • Animals were exposed to normoxemia and hypoxemia (inspired oxygen fraction 0.10) before and after naloxone hydrochloride administration.

    • Main Results:

    • Naloxone did not significantly alter basal core temperature or the hypoxemic core temperature response in either age group.
    • Naloxone decreased basal oxygen consumption in both newborn and older guinea pigs.
    • Naloxone altered thermoregulatory mechanisms for decreasing core temperature during hypoxemia specifically in newborn guinea pigs.

    Conclusions:

    • The data do not support the hypothesis that endogenous opioids mediate the regulated decrease in core body temperature during acute hypoxemia.
    • Opioid systems may influence metabolic rate and thermoregulatory strategies, but not the primary hypothermic response to hypoxemia.