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Related Experiment Videos

47,XYY karyotypes and pervasive developmental disorders

R Nicolson1, S Bhalerao, L Sloman

  • 1Department of Psychiatry, University of Toronto, Ontario. nicolson@box-n.nih.gov

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|September 8, 1998
PubMed
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This study presents two boys with pervasive developmental disorders (PDDs) and a 47, XYY karyotype. The findings suggest a potential increase in this sex chromosome anomaly among males with PDDs.

Area of Science:

  • Genetics
  • Neurodevelopmental Disorders
  • Pediatrics

Background:

  • The 47, XYY karyotype is a sex chromosome anomaly in males.
  • Pervasive developmental disorders (PDDs) encompass a range of neurodevelopmental conditions.
  • The co-occurrence of 47, XYY karyotype and PDDs is infrequently documented.

Observation:

  • Two male patients with PDDs were identified with a 47, XYY karyotype.
  • One patient presented with autistic disorder, the other with PDD not otherwise specified.
  • These cases were identified from a clinic population of 40 male referrals for developmental disorders.

Findings:

  • The prevalence of the 47, XYY karyotype may be elevated in males with PDDs.
  • The study reviewed literature on psychosocial development, brain morphology, and physiology in males with 47, XYY karyotypes.

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  • An extra Y chromosome might be associated with altered brain development.

    • Implications:

    • Increased awareness of the 47, XYY karyotype in the PDD population is warranted.
    • Further research into the relationship between the 47, XYY karyotype and neurodevelopmental pathways is needed.
    • Understanding this association may inform early identification and intervention strategies for vulnerable males.