Related Experiment Videos
Cbfa1 in bone development
1Department of Medicine III, Osaka University Medical School, Japan. Science and Technology Corporation, Japan. komorit@imed3.med.osaka-u.ac.jp
Current Opinion in Genetics & Development
|September 8, 1998
Abstract:
A factor fundamental to bone formation has been identified. Gene targeting shows that core-binding factor alpha 1 (Cbfa1) plays an essential role in bone formation and osteoblast differentiation. Thus, it is now possible to begin examining the molecular mechanism of bone formation--especially osteoblast differentiation.