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[Cholestatic hepatitis associated with piroxicam use. Case report]
J Poniachik1, J Guerrero, P Calderón
1Laboratorio PCR-Gastroenterología, Hospital Clínico, Universidad de Chile.
Revista Medica De Chile
|September 10, 1998
Summary
Piroxicam, a nonsteroidal anti-inflammatory drug, can cause acute cholestatic hepatitis. This rare drug-induced liver injury necessitates vigilance with prolonged NSAID use.
Area of Science:
- Hepatology
- Pharmacology
- Toxicology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly associated with potential hepatotoxicity.
- Drug-induced liver injury (DILI) presents a diagnostic challenge, especially with less common presentations.
Observation:
- A 22-year-old female developed acute cholestatic hepatitis following extended piroxicam use.
- Clinical presentation included jaundice and elevated liver enzymes, indicative of cholestasis.
Findings:
- Hepatitis was definitively linked to piroxicam due to negative viral and autoimmune markers.
- Histopathological examination supported drug-induced etiology.
- Favorable recovery was observed upon discontinuation of piroxicam.
Implications:
- This case highlights the uncommon but serious risk of piroxicam-induced cholestatic hepatitis.
- Clinicians should consider DILI in patients with unexplained hepatitis, particularly those on long-term NSAID therapy.