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Protein structure and dynamics at high pressure
1Department of Chemistry, Katholieke Universiteit Leuven, Belgium. Karel.Heremans@fys.kuleuven.ac.be
Biochimica Et Biophysica Acta
|September 12, 1998
Abstract:
The effect of pressure on the structure and dynamics of proteins is discussed in the framework of the pressure-temperature stability phase diagram. The elastic (reversible) properties, thermal expansion, compressibility and heat capacity, are correlated with the entropy, volume, and the coupling between entropy and volume fluctuations respectively. The experimental approaches that can be used to measure these quantities are reviewed. The plastic (conformational) changes reflect the changes in these properties in the cold, pressure and heat denaturation.