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Leucocyte filterability: comparing diluted with undiluted blood

A M Cook1, S A Evans, I F Lane

  • 1School of Molecular and Medical Biosciences, University of Wales, Cardiff.

British Journal of Haematology
|September 12, 1998
PubMed
Summary
This summary is machine-generated.

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White blood cells (leukocytes) affect blood flow through filters. A subset of these cells, identified by declining flow rates, can be counted and analyzed for rheological properties, especially in disease.

Area of Science:

  • Hematology
  • Biophysics
  • Rheology

Background:

  • Red blood cells and most white blood cells (leukocytes) immediately impact blood flow through microfilters.
  • A small subset of leukocytes influences flow over time, causing a continuous decline in flow rate.

Observation:

  • Analysis of declining flow rates in 5-micrometer filters allows for leukocyte counting and rheological property assessment.
  • Approximately 50% of slow leukocytes pass through filters within 30 seconds, while others act as pore blockers for 150 seconds.

Findings:

  • Leukocyte numbers and flow properties were similar in young women and older men.
  • Increased slow leukocyte counts were observed in older men with peripheral arterial occlusive disease.
  • Blood dilution with phosphate-buffered saline increased slow leukocytes in older individuals, particularly patients, but not younger ones.

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Implications:

  • Filtration studies for leukocyte rheology should be conducted with undiluted blood.
  • Dilution effects on leukocyte properties may indicate ex vivo changes or inherent cellular differences.
  • This method offers potential for diagnosing and understanding conditions affecting blood flow and leukocyte behavior.