Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type

A Salehi1, E J Dubelaar, M Mulder

  • 1Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands. A.Salehi@nih.knaw.nl

Proceedings of the National Academy of Sciences of the United States of America
|September 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interval type-2 Fuzzy control and stochastic modeling of COVID-19 spread based on vaccination and social distancing rates.

Computer methods and programs in biomedicine·2023
Same author

Relationship between styrene exposure and prolactin secretion in human and animal studies: A systematic review.

Human & experimental toxicology·2022
Same author

Comparison of Indocyanine Green Angiography and Fluorescein Angiography for Imaging of Central Serous Chorioretinopathy Patients as Candidates for Photodynamic Therapy.

Journal francais d'ophtalmologie·2022
Same author

Large-scale potential RNA editing profiling in different adult chicken tissues.

Animal genetics·2019
Same author

Comparing the effect of colactive plus ag dressing versus nitrofurazone and vaseline gauze dressing in the treatment of second-degree burns.

Annals of burns and fire disasters·2019
Same author

Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide.

Journal of psychiatric research·2018
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Alzheimer's disease (AD) reduces nucleus basalis neuron metabolic activity. This decrease is worsened by the apolipoprotein E (ApoE) epsilon4 allele, indicating ApoE epsilon4's role in AD pathogenesis via reduced neuronal metabolism.

Area of Science:

  • Neuroscience
  • Genetics
  • Pathology

Background:

  • Nucleus basalis neuron metabolic activity is significantly reduced in Alzheimer's disease (AD) patients.
  • The apolipoprotein E (ApoE) epsilon4 genotype is a major genetic risk factor for AD.

Purpose of the Study:

  • To investigate whether the reduced metabolic activity in nucleus basalis neurons in AD is dependent on the apolipoprotein E (ApoE) genotype.
  • To determine the specific impact of the ApoE epsilon4 allele on neuronal metabolism in AD.

Main Methods:

  • Neuronal metabolic activity was assessed by measuring the size of the Golgi apparatus (GA) in the nucleus basalis of Meynert.
  • Immunohistochemistry using an antibody against MG-160, a Golgi apparatus sialoglycoprotein, was employed to visualize the GA.
  • Image analysis was used to quantify GA size in 30 control and 41 AD patients with known ApoE genotypes.

Related Experiment Videos

Main Results:

  • A significant reduction in Golgi apparatus size was observed in the nucleus basalis of AD patients compared to controls.
  • AD patients carrying one or two ApoE epsilon4 alleles exhibited a further, significant decrease in Golgi apparatus size compared to AD patients without ApoE epsilon4 alleles.

Conclusions:

  • The decreased metabolic activity of nucleus basalis neurons in Alzheimer's disease is dependent on the ApoE epsilon4 genotype.
  • These findings suggest that ApoE epsilon4 contributes to AD pathogenesis by impairing neuronal metabolism.