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Does measles really predispose to tuberculosis?

J A Flick

    The American Review of Respiratory Disease
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Measles does not appear to activate tuberculosis, contrary to common belief. Current evidence is insufficient to support claims that measles adversely impacts tuberculosis or immunity.

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    Area of Science:

    • Immunology
    • Infectious Diseases
    • Public Health

    Background:

    • Textbooks and reviews commonly cite measles as adversely influencing tuberculosis.
    • This claim is prevalent in discussions of cellular immunity and disease mechanisms.

    Purpose of the Study:

    • To critically investigate the medical literature supporting the claim that measles activates tuberculosis.
    • To evaluate the evidence for measles's influence on tuberculous lesions and immunity.

    Main Methods:

    • A critical review of existing medical literature and field studies.
    • Assessment of data quality and collection methods in relevant studies.

    Main Results:

    • Field studies reviewed had significant deficiencies in data and methodology, invalidating conclusions.

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  • Inadequate epidemiologic data exist to support measles suppressing tuberculin skin reactivity or tuberculous immunity.

    • Conclusions:

    • The claim that measles activates tuberculosis is not supported by current valid evidence.
    • Any deleterious influence of measles on tuberculosis likely occurs infrequently in most populations.