Related Experiment Video
Updated: Jul 29, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Case report: Insulin-like growth factor II expression in hepatocellular carcinoma with alcoholic liver fibrosis
M Yamaguchi1, S Kamimura, J Takada
1Department of Internal Medicine, Fukuoka Red Cross Hospital, Japan.
Abstract:
This case of hepatocellular carcinoma (HCC) with alcoholic liver fibrosis, which was not associated with hepatitis viruses, was accompanied by hypoglycaemia. The immunoreactive insulin level was low and other hormonal examinations were almost normal. Immunohistochemical studies showed a high level of insulin-like growth factor II (IGF2) peptide in the HCC section and the size heterogeneity of serum IGF2 investigated by western blot revealed a large form at approximately 15 kDa. These results suggest that the HCC with alcoholic liver fibrosis produced IGF2 and that the hypoglycaemia was caused by tumour-associated IGF2.
More Related Videos
07:47Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
Published on: August 31, 2022
07:32Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
Published on: April 12, 2024
Related Concept Videos
Hypoglycemia and Glucagon
Type I Diabetes II: Pathophysiology
Type II Diabetes II: Pathophysiology
Cirrhosis I: Introduction
Cirrhosis II: Pathophysiology
Chronic Pancreatitis II: Pathophysiology