Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective serotonin reuptake inhibitor utilization patterns: consistency across research designs

D S Hutchins1, E G Klein, W F Signa

  • 1Outcomes Research, PCS Health Systems, Inc., Scottsdale, Arizona 85260-6719, USA.

Clinical Therapeutics
|September 16, 1998
PubMed
Summary

Relaxed selection criteria for antidepressant therapy studies increase patient stability rates. Fluoxetine demonstrated consistent stability across designs, unlike paroxetine and sertraline.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does the type of CIA policy significantly affect bar and restaurant employment in Minnesota cities?

Prevention science : the official journal of the Society for Prevention Research·2009
Same author

The relationship between local clean indoor air policies and smoking behaviours in Minnesota youth.

Tobacco control·2008
Same author

Components of partial resistance in the slash pine-fusiform rust pathosystem.

Phytopathology·2008
Same author

The European Schizophrenia Outpatient Health Outcomes (SOHO) study: rationale, methods and recruitment.

Acta psychiatrica Scandinavica·2003
Same author

A community-based collaboration to assess and improve medical insurance status and access to health care of Latino children.

Public health reports (Washington, D.C. : 1974)·2002
Same author

A simple method for predicting the consequences of land management in urban habitats.

Environmental management·2001

Area of Science:

  • Pharmacotherapy
  • Clinical Trial Design
  • Mental Health Research

Background:

  • Antidepressant therapy initiation is complex.
  • Patient adherence to initial treatment regimens is crucial for efficacy.
  • Commonly applied selection criteria in studies may impact observed outcomes.

Purpose of the Study:

  • To evaluate how typical versus relaxed selection criteria affect the achievement of stable antidepressant therapy patterns.
  • To compare the stability of fluoxetine, paroxetine, and sertraline under different study designs.

Main Methods:

  • Analysis of a large US prescription database for patients initiating fluoxetine, paroxetine, or sertraline between February and April 1995.
  • Categorization of patients into 'typical design' (with strict criteria) and 'relaxed design' (without strict criteria) groups.

Related Experiment Videos

  • Determination of the percentage of patients achieving a stable pattern (90+ consecutive days on initial agent/dose).

    • Main Results:

    • A higher percentage of patients achieved stable therapy with the relaxed design (32.4%) compared to the typical design (28.8%).
    • Patients initiating fluoxetine therapy showed significantly higher stability rates (>5.5% increase) compared to paroxetine or sertraline.
    • Fluoxetine's stability was consistent across both designs, while paroxetine and sertraline showed mixed results.

    Conclusions:

    • Relaxed selection criteria in clinical studies can lead to higher observed rates of stable antidepressant use.
    • The choice of selection criteria may influence the representativeness of study samples and underestimate pharmacotherapy benefits.
    • Fluoxetine's treatment stability is robust across different study designs, offering a reliable option.