Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteoinduction using bone morphogenic protein in irradiated tissue

B K Howard1, K R Brown, J L Leach

  • 1Department of Otorhinolaryngology, University of Texas Southwestern Medical Center, Dallas 75235-9035, USA.

Archives of Otolaryngology--Head & Neck Surgery
|September 17, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of ultrasonic energy on peripheral nerves: implications for ultrasound-assisted liposuction.

Plastic and reconstructive surgery·1999
Same author

The tissue effects of ultrasound-assisted lipoplasty.

Plastic and reconstructive surgery·1998
Same author

Use of a screening RAST in a large neuro-otologic practice.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·1998
Same author

Prevention of flash fires during facial surgery performed under local anesthesia.

The Annals of otology, rhinology, and laryngology·1997
Same author

Galanin inhibits cholecystokinin secretion in STC-1 cells.

Biochemical and biophysical research communications·1995
Same author

Angiotensin IV receptors and signaling in opossum kidney cells.

The American journal of physiology·1995

Recombinant bone morphogenic protein 2 (rBMP-2) effectively promotes bone growth in irradiated tissue, showing promise for reconstructive surgery in head and neck cancer patients.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Surgical Oncology

Background:

  • Radiation therapy for head and neck cancer can compromise tissue for bony reconstruction.
  • Osteoinductive agents are crucial for enhancing bone formation in challenging surgical sites.

Purpose of the Study:

  • To evaluate the osteoinductive efficacy of recombinant bone morphogenic protein 2 (rBMP-2) in irradiated rabbit tissue.
  • To assess the combination of rBMP-2 with solid hydroxyapatite for bone regeneration.

Main Methods:

  • Prospective randomized controlled trial in New Zealand rabbits.
  • Implantation of hydroxyapatite disks with or without rBMP-2 into irradiated and non-irradiated tissue beds.
  • Histological analysis at 3, 6, and 20 weeks post-implantation.

Related Experiment Videos

Main Results:

  • rBMP-2 demonstrated equal osteoinductive efficacy in both irradiated and non-irradiated tissues.
  • Significantly greater new bone formation was observed in the rBMP-2 treated group compared to the buffer control group.
  • Histological analysis confirmed bone regeneration at various time points.

Conclusions:

  • rBMP-2 combined with hydroxyapatite is a viable option for bone regeneration in irradiated tissues.
  • These findings support the clinical application of rBMP-2 in patients requiring bony reconstruction after radiation therapy.
  • The study highlights potential improvements in reconstructive surgery outcomes for head and neck cancer patients.