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Updated: Aug 10, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Association of extracellular-superoxide dismutase phenotype with the endothelial constitutive nitric oxide synthase
1Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan. adachi@gifu-pu.ac.jp
Abstract:
The distribution of extracellular-superoxide dismutase (EC-SOD) levels in healthy Australian subjects was consistent with two distinct phenotypes in which the smaller group of subjects (3.3%) had 15-fold higher levels. The EC-SOD levels in individuals homozygous for endothelial constitutive nitric oxide synthase 4a (ecNOS4a), a rare allele for ecNOS repeat polymorphism at intron 4, were significantly lower than those in ecNOS4A/a and ecNOS4AIA subjects. Furthermore, NO levels were negatively correlated with the EC-SOD levels in common EC-SOD phenotype subjects. Whilst the mechanism remains speculative, it is possible that there is a significant interaction between EC-SOD and ecNOS, or that common factor(s), either genetic or environmental, influence both of them.
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