Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytomegalovirus infection

H L Brown1, M P Abernathy

  • 1Division of Maternal Fetal Medicine, Indiana University School of Medicine, Indianapolis, USA.

Seminars in Perinatology
|September 17, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying regeneration in patients following peripheral nerve injury.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2019
Same author

Tetrazolium reduction allows assessment of biofilm formation by Campylobacter jejuni in a food matrix model.

Journal of applied microbiology·2013
Same author

Cervical dilation as a predictor of pregnancy outcome following emergency cerclage.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2012
Same author

Climate change and air quality: the potential impact on health.

Asia-Pacific journal of public health·2011
Same author

Cervicovaginal fistula presenting during miscarriage.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2010
Same author

Indoor air pollution from biomass combustion and respiratory symptoms of women and children in a Zimbabwean village.

Indoor air·2007
Same journal

Congenital cytomegalovirus: Screening strategies and diagnostic challenges.

Seminars in perinatology·2026
Same journal

The society for neonatal nutrition and lifelong health: Building science and translating research to inform neonatal nutritional care.

Seminars in perinatology·2026
Same journal

Enteral nutrition to optimize health and neurodevelopmental outcomes in very preterm infants.

Seminars in perinatology·2026
Same journal

Standardizing outcome measures in preterm infant nutrition research: Use of anthropometry and body composition in the neonatal intensive care unit.

Seminars in perinatology·2026
Same journal

A dilemma of parental inclusion? Parent perspectives of NICU feeding practices and neonatal nutritional research.

Seminars in perinatology·2026
Same journal

Maternal diet and nutritional status during pregnancy and lactation: a review of implications on milk composition and lactation outcomes.

Seminars in perinatology·2026
See all related articles

Cytomegalovirus (CMV) is a common perinatal infection. Primary CMV in mothers can cause congenital infections, leading to high mortality and severe neurological issues in infants, emphasizing the need for prevention education.

Area of Science:

  • Perinatology
  • Virology
  • Pediatric Infectious Diseases

Background:

  • Cytomegalovirus (CMV) infection is the most frequent perinatal infection, posing significant risks to fetal development.
  • Congenital CMV infections occur in 40-50% of infants born to mothers with primary CMV infection.
  • While many infected infants are asymptomatic at birth, a substantial percentage develop long-term sequelae.

Purpose of the Study:

  • To review the epidemiology and clinical outcomes of congenital Cytomegalovirus (CMV) infection.
  • To highlight the risks associated with primary versus recurrent CMV infections during pregnancy.
  • To underscore the importance of preventive measures due to limitations in current therapies.

Main Methods:

  • Review of existing literature on Cytomegalovirus (CMV) perinatal infections.

Related Experiment Videos

  • Analysis of data regarding congenital infection rates, symptomatic presentation, mortality, and long-term morbidity.
  • Evaluation of risks associated with different maternal CMV infection statuses and modes of transmission.

    • Main Results:

    • Primary maternal CMV infection leads to congenital infection in 40-50% of neonates, with 5-18% symptomatic at birth.
    • Mortality in symptomatic congenitally infected infants approaches 30%, and 80% of survivors experience severe neurological morbidity.
    • Asymptomatic infants may develop sequelae like visual and auditory defects in 10-15% of cases; recurrent/reactivated infections pose minimal fetal risk.

    Conclusions:

    • Congenital Cytomegalovirus (CMV) infection, particularly from primary maternal infections, presents a major threat to fetal health, causing significant mortality and morbidity.
    • Preventive strategies are crucial as current antimicrobial therapies and immunoprophylaxis for CMV are inadequate.
    • Educating pregnant women on CMV prevention is essential to mitigate the impact of this common perinatal infection.