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[Pemphigoid vegetans. An immunoelectron microscopic study]

N Delpuget-Bertin1, P Bernard, C Bedane

  • 1Service de Dermatologie, Hôpital Dupuytren, Limoges.

Annales De Dermatologie Et De Venereologie
|January 1, 1997
PubMed
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Pemphigoid vegetans, a rare blistering skin disease, presents like pemphigus vegetans but shows features of bullous pemphigoid. This case suggests it is a bullous pemphigoid subtype, with notable improvement using tetracyclines.

Area of Science:

  • Dermatology
  • Immunodermatology
  • Pathology

Background:

  • Pemphigoid vegetans is a rare autoimmune blistering disease.
  • It clinically mimics pemphigus vegetans but exhibits bullous pemphigoid histopathological and immunopathological features.

Observation:

  • A 57-year-old male presented with intertriginous vegetating plaques.
  • Skin biopsy revealed histological and direct immunofluorescence findings consistent with bullous pemphigoid.
  • Direct immunoelectron microscopy further supported a diagnosis of bullous pemphigoid.

Findings:

  • Immunoblot and indirect immunofluorescence studies of salt-split skin were negative.
  • The case presented here is the first to include direct immunomicroscopic findings.
  • These findings suggest pemphigoid vegetans is a subtype of bullous pemphigoid.

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Implications:

  • This study contributes to classifying pemphigoid vegetans within the spectrum of bullous pemphigoid.
  • The remarkable clinical improvement observed with tetracycline therapy warrants further investigation for this treatment modality.