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Cell cycle: oiling the gears of anaphase
1Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94305, USA.
Current Biology : CB
|September 19, 1998
Abstract:
The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of proteins that control specific steps in mitosis. Recent studies show that APC activity requires WD40 domain proteins, and that one of these proteins is part of the checkpoint control that ensures accurate chromosome segregation.