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[Coronary involvement in systemic lupus erythematosus]

G Lair1, P Joly, G Desrumeaux

  • 1Clinique dermatologique, Hôpital Charles Nicolle, Rouen.

Annales De Dermatologie Et De Venereologie
|January 1, 1997
PubMed
Summary

Coronary artery disease is rare in lupus erythematosus. In patients with lupus and antiphospholipid antibodies, smoking may contribute to coronary artery disease development.

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Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Coronary artery disease (CAD) is infrequently observed in patients with systemic lupus erythematosus (SLE).
  • The underlying mechanisms of coronary occlusion in SLE are complex and multifactorial.
  • This report details three SLE patients diagnosed with CAD via coronary angiography, who also presented with antiphospholipid antibodies.

Observation:

  • Three young SLE patients (21-35 years) developed CAD 3-11 years post-SLE onset.
  • All patients tested positive for antiphospholipid antibodies and had received corticosteroid therapy.
  • Coronary angiography revealed coronary occlusion in two patients and myocardial microvasculopathy in one; SLE was quiescent at the time of CAD diagnosis.

Findings:

  • Antiphospholipid antibodies were present in all three patients with SLE and CAD.

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  • Smoking was identified as a potential contributing factor in two of the three patients.
  • The combination of antiphospholipid antibodies and smoking may play a role in the pathogenesis of CAD in this cohort.

    • Implications:

    • Highlights a potential link between antiphospholipid antibodies, smoking, and CAD in SLE patients.
    • Suggests the need for cardiovascular risk assessment in SLE patients with antiphospholipid antibodies, particularly those who smoke.
    • Underscores the complex interplay of factors contributing to cardiovascular complications in systemic lupus erythematosus.