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Hemorheological parameters in coronary artery disease
1Cardiology Center, University Medical School of Pecs, Hungary.
Insights
Altered hemorheological parameters, including fibrinogen and viscosity, are linked to the severity of coronary artery disease (CAD). These blood flow properties may contribute to the development of ischemic heart disease (IHD).
Area of Science:
- Cardiovascular Medicine
- Hematology
Background:
- Hemorheological parameters are established risk factors for ischemic heart disease (IHD).
- Understanding the relationship between hemorheology and coronary artery disease (CAD) severity is crucial for risk stratification.
Purpose of the Study:
- To investigate the association between hemorheological parameters and the severity of coronary artery disease (CAD).
Main Methods:
- Analysis of hemorheological parameters (hematocrit, fibrinogen, plasma viscosity (PV), whole blood viscosity (WBV), circulatory index (CRI)) in 109 CAD patients and 59 controls.
- Classification of patients into groups based on coronary angiogram findings: no significant CAD, single-vessel disease, and multi-vessel disease.
Main Results:
- IHD patients exhibited significantly higher hemorheological parameters compared to controls.
- Fibrinogen and PV were elevated in single and multi-vessel disease groups versus the no-CAD group.
- Hematocrit and WBV increased significantly with disease severity (multi-vessel disease).
- Circulatory index (CRI) was reduced in IHD patients, particularly in the multi-vessel disease group.
Conclusions:
- Hemorheological alterations are associated with the severity of coronary artery disease.
- These parameters may play a significant role in the pathogenesis and progression of CAD.
Abstract:
Hemorheological parameters are primary risk factors in ischemic heart disease (IHD). In the present study the relation of these parameters to the severity of coronary artery disease (CAD) was examined. The data of 109 patients (mean age: 55+/-9 years) undergoing coronary angiography and 59 healthy controls (mean age:35+/-10 years) were analyzed. Hemorheological parameters (hematocrit, fibrinogen level, plasma viscosity (PV) and apparent whole blood viscosity (WBV)) were determined and the circulatory index (CRI) was calculated. Patients were classified into three groups according to their coronary vessel state based on the coronary angiogram: Group 1 (n = 19, mean age: 53+/-8 years) without significant CAD, Group 2 (n = 19, mean age: 51+/-11 years) with single vessel disease, Group 3 (n = 71, mean age: 57+/-8 years) with multivessel disease. All the measured hemorheological parameters of IHD patients were significantly higher than those of controls. Fibrinogen and PV were significantly elevated in Groups 2 and 3 compared with Group 1 (p < 0.05 and 0.01). Hematocrit and WBV were significantly increased in Group 3 compared with Groups 1 and 2 (p < 0.05). CRI was significantly decreased in IHD patients, and it was also lower in Group 3 than in Group 2 (p < 0.05). These results indicate that hemorheological parameters may play a role in the pathogenesis and development of CAD.