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[Modulation of the antiarrhythmic effect by endogenous opioids during adaptation to hypoxia in rats]
Iu B Lishmanov1, E V Uskina, A V Krylatov
1Institute of Cardiology, Tomsk, Russia.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|September 22, 1998
Abstract:
Adaptation of rats to hypoxia increased the heart resistance against arrhythmogenic effects. The Met-enkephaline-Arg6-Phe7 contant increased in the hypothalamus of the adapted animals. The blockers of mu- and delta-opioid receptors reduced the antiarrhythmic effect of the adaptation, whereas chi-receptor inhibitor, nor-binaltorphimine, completely abolished it. The findings suggest the antiarrhythmic effect depends on an increase of the endogenous opioids level and modulated effect of these peptides upon autonomous nervous system.