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[Effect of opioid peptides on immunomodulation]
1Institute of Physiology of the Russian Acad. Med. Sci., Siberian Branch, Novosibirsk.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|September 22, 1998
Summary
Opioid receptor agonists differentially affect immune responses in mice. Delta and kappa agonists suppressed immunity, while mu agonists stimulated it, with the hypothalamo-hypophyseal connection mediating these effects.
Area of Science:
- Neuroimmunology
- Pharmacology
Context:
- Opioid receptors play a role in modulating immune function.
- The central nervous system influences immune responses.
Purpose:
- To investigate the effects of specific opioid receptor agonists on immune cell activity in mice.
- To explore the role of the hypothalamo-hypophyseal connection in mediating these opioid-induced immune effects.
Summary:
- Delta-agonist DSLET and kappa-agonist rimorphin significantly inhibited plaque-forming and rosette-forming cells in CBA mice.
- Mu-agonist DAGO stimulated the immune response on days 4 and 5 post-immunization with SRBC.
- Lesioning the hypothalamo-hypophyseal connection abolished both immuno-stimulating and immuno-depressive effects.
Impact:
- Opioid receptor activation has differential effects on the immune system.
- The hypothalamo-hypophyseal connection is crucial for mediating opioid-induced neuro-immune interactions.
- Serotoninergic and dopaminergic systems are implicated in the immuno-depressive and immuno-stimulating effects, respectively.