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Hormonal profiles after the menopause

S Chakravarti, W P Collins, J D Forecast

    British Medical Journal
    |October 2, 1976
    PubMed
    Summary
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    Menopause significantly alters hormone levels, with a sharp decline in androstenedione, oestrone, and oestradiol, alongside a rise in follicle-stimulating hormone (FSH) and luteinising hormone (LH). Hormone levels stabilize over time post-menopause.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Menopause Research

    Background:

    • The menopausal transition involves significant hormonal shifts.
    • Understanding these endocrinological changes is crucial for women's health.
    • Previous studies have characterized some, but not all, hormonal changes during postmenopause.

    Purpose of the Study:

    • To define the endocrinological changes during the climacteric.
    • To analyze hormone concentrations in postmenopausal women over time.
    • To correlate hormone levels with years since menopause.

    Main Methods:

    • Studied 60 healthy postmenopausal women grouped by years since menopause.
    • Measured serum concentrations of FSH, LH, androstenedione, testosterone, oestrone, and oestradiol.

    Related Experiment Videos

  • Compared hormone levels to early proliferative phase of the menstrual cycle.

    • Main Results:

    • One year post-menopause: androstenedione, oestrone, oestradiol decreased to ~20% of premenopausal levels.
    • FSH and LH increased significantly, peaking at 2-3 years post-menopause.
    • Testosterone levels decreased post-menopause; androstenedione showed a transient increase.
    • Oestradiol levels unexpectedly rose in later postmenopause.

    Conclusions:

    • Menopause triggers profound hormonal shifts, including decreased ovarian steroids and increased gonadotropins.
    • Hormonal profiles evolve over decades following menopause.
    • Further research is needed to explain the late increase in oestradiol levels.