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[Erythema multiforme caused by saquinavir]

H Garat1, F el Sayed, M Obadia

  • 1Département de Dermatologie, Vénéréologie et Allergologie, Centre Hospitalier Universitaire Purpan, Toulouse.

Annales De Dermatologie Et De Venereologie
|September 25, 1998
PubMed
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This study reports the first case of erythema multiforme, a rare skin reaction, associated with saquinavir, an HIV protease inhibitor. The patient

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Saquinavir is a protease inhibitor used in HIV treatment.
  • Adverse skin reactions to saquinavir are uncommon.
  • Erythema multiforme is a distinct mucocutaneous reaction pattern.

Observation:

  • A 32-year-old HIV-positive male developed skin and oral lesions five days after starting saquinavir.
  • Lesions were characterized as maculo-papular with bullous centers and erosive palate lesions.
  • Histological examination confirmed erythema multiforme.

Findings:

  • Saquinavir was identified as the causative agent for erythema multiforme in this patient.
  • Discontinuation of saquinavir led to the regression of skin and mucosal lesions within 15 days.

Related Experiment Videos

  • No recurrence was observed at the 3-month follow-up.

    • Implications:

    • This case highlights an exceptionally rare adverse skin reaction to saquinavir.
    • Structural similarities among protease inhibitors may pose challenges in selecting alternative treatments.
    • Clinicians should consider saquinavir as a potential cause of erythema multiforme in HIV patients.