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[Plasma tryptophan bioavailability during chronic urticaria]

M A Richard1, F Serres, P Giravalli

  • 1Service de Dermatologie, Hôpital Sainte Marguerite, Marseille.

Annales De Dermatologie Et De Venereologie
|September 25, 1998
PubMed
Summary
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Erythrocyte tryptophan transport is not significantly different in chronic idiopathic urticaria patients. This study suggests tryptophan bioavailability and serotonin dysfunction are unlikely causes of chronic urticaria.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Dermatology

Context:

  • Chronic idiopathic urticaria (CIU) is a condition with a known psychogenic component.
  • Current psychological assessments fail to identify specific psychological profiles in CIU patients.
  • Tryptophan (TRP) transport by erythrocytes influences brain serotonin synthesis, potentially offering a biochemical marker for CIU.

Purpose:

  • To investigate erythrocyte-specific L-tryptophan (TRP) influx kinetics in chronic idiopathic urticaria (CIU) patients.
  • To explore the potential of TRP transport as a biochemical marker for CIU, distinct from psychological evaluations.
  • To correlate TRP influx rates with anxiety and depression scores in CIU patients.

Summary:

  • A kinetic study of L-TRP influx into erythrocytes was performed on 17 CIU patients and 35 healthy controls.

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  • While mean Vmax (maximum L-TRP-specific influx) did not differ significantly, CIU patients showed wide Vmax dispersion, with over 50% having perturbed influx.
  • No correlation was found between Vmax and psychological scores for anxiety or depression.

    • Impact:

    • Erythrocyte TRP transport does not appear to be globally perturbed in CIU.
    • Findings do not support a link between altered TRP bioavailability, central serotoninergic dysfunction, and CIU.
    • This research highlights the complexity of CIU pathophysiology beyond simple tryptophan transport mechanisms.