Related Experiment Video
Updated: Aug 3, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Epidermolysis bullosa acquisita and hepatitis C]
S Thiery1, L Misery, P Chossegros
1Clinique Dermatologique, Hôpital Edouard Herriot, Lyon.
Introduction:
Epidermolysis bullosa acquisita is a bullous dermatosis. Its etiology remains unknown and the efficacy of its treatment is low.
Observation:
We report the first association between epidermolysis bullosa acquisita, chronic hepatitis C and cryoglobulinemia, healing with interferon alpha and ribavirine.
Discussion:
We suggest a role for hepatitis C virus in the pathogenesis of epidermolysis bullosa acquisita. We suppose a synthesis of autoimmune antibodies in a dysimmune environment. Interferon alpha and ribavirine might be a new therapeutic avenue but further studies are necessary to confirm it.
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