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[Membrane metalloendopeptidase (CD10/CALLA): distribution, physiologic and pathophysiologic functions and its
1Institut Ruder Bosković Zavod za molekularnu medicinu, Laboratorij za eksperimentalnu hematologiju, imunologiju i onkologiju, Zagreb.
Lijecnicki Vjesnik
|September 28, 1998
Summary
Membrane metalloendopeptidase (CD10/NEP) cleaves regulatory peptides in various organs. Inhibitors of this enzyme show therapeutic potential for pain, hypertension, and asthma.
Area of Science:
- Biochemistry
- Molecular Biology
- Immunology
Context:
- Membrane metalloendopeptidase (EC 3.4.24.11), also known as enkephalinase or neutral endopeptidase (NEP), is a cell surface ectoenzyme.
- Identified by CD10 or CALLA, it's found in various organs including the brain, cardiovascular system, lungs, placenta, and kidneys.
- CD10 is a marker for lymphoblasts in acute lymphoid leukemia lacking T- or B-cell markers.
Purpose:
- To investigate the role and substrates of CD10/NEP in different physiological systems.
- To explore the therapeutic potential of CD10/NEP inhibitors.
Summary:
- CD10/NEP enzymatically cleaves diverse regulatory peptides such as enkephalins, oxytocin, substance P, and angiotensin II.
- Substrate specificity varies by tissue, with examples including ANP in kidneys, enkephalins in the brain, and substance P in the lungs.
- The enzymatic activity of CD10/NEP may influence lymphocyte development.
Impact:
- CD10/NEP inhibitors like thiorphan are being investigated for treating pain, diarrhea, depression, hypertension, and asthma.
- Potential applications also include managing hyalinomembranous disease and preventing neurotoxicosis from tetanus and botulism.