[The paradox of disseminated intravascular coagulation]

Disseminated intravascular coagulation (DIC) is an abnormal extension of a coagulation process normally limited in time and space. DIC results from the release of free thrombin in circulating blood, as thrombin synthesis and inactivation mechanisms non longer function properly. In addition to microthrombosis, acute DIC may lead to haemorrhage related to activation of the coagulation process. According to the disease aetiology, emergency treatment may become a top priority, in case of haemorrhage, shortage of platelets and coagulation factors related to increased use of these blood components requires replacement treatment with infusion of platelets and fresh frozen plasma. As treatment of the procoagulation process, heparin should not be recommanded in acute DIC with haemorrhage. Based on rational theoretical data, current evaluation of antithrombin therapy is in progress.