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[Basedow's disease and thyroid nodules. A common association]

J L Kraimps1, M H Bouin-Pineau, R Maréchaud

  • 1Service de Chirurgie Endocrinienne, Hôpital Jean-Bernard, Poitiers.

Annales De Chirurgie
|September 30, 1998
PubMed
Summary
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Graves' disease patients undergoing surgery have a notable rate of incidentally discovered papillary thyroid cancer. Surgery is valuable for Graves' disease patients with thyroid nodules.

Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Context:

  • Graves' disease is an autoimmune disorder leading to hyperthyroidism.
  • The co-occurrence of Graves' disease and thyroid cancer is debated.
  • Surgical management is a common treatment for Graves' disease.

Purpose:

  • To determine the frequency of thyroid cancer in patients with Graves' disease undergoing surgery.
  • To evaluate the diagnostic yield of pre-operative assessments for malignancy in this cohort.

Summary:

  • A retrospective study analyzed 110 patients operated for Graves' disease (1991-1996).
  • Thyroid nodules were found in 28 patients, with 6 diagnosed as papillary carcinoma (5.5% of all Graves' patients, 21.4% of those with nodules).
  • No patients had prior radiation exposure.

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Impact:

  • Highlights the significant prevalence of incidental thyroid cancer in Graves' disease patients requiring surgery.
  • Supports the consideration of surgical intervention for Graves' disease when thyroid nodules are present.
  • Informs clinical decision-making regarding the workup and management of Graves' disease patients with nodules.