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Related Experiment Videos

Measles vaccination before nine months

K George1, A Joseph, J Muliyil

  • 1Department of Community Health, Christian Medical College, Vellore, India.

Tropical Medicine & International Health : TM & IH
|October 1, 1998
PubMed
Summary

Administering the measles vaccine between 6-8 months is safe and effective, significantly reducing mortality risk in children. Early vaccination offers crucial protection against measles, especially in high-risk areas.

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Area of Science:

  • Immunology
  • Pediatrics
  • Public Health

Background:

  • Measles vaccination is critical for child survival.
  • Early childhood immunization is a key public health strategy.
  • Understanding optimal measles vaccine timing is essential.

Purpose of the Study:

  • To evaluate the protective efficacy of measles vaccine given before 9 months of age.
  • To compare mortality rates in children vaccinated at 6-8 months versus 9-11 months.

Main Methods:

  • A non-concurrent cohort study of 13,134 children born between 1986-1991.
  • Assessed disease and death risks based on measles immunization age.
  • Follow-up included children under five years of age.

Main Results:

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  • Unimmunized children faced higher measles and mortality risks (P < 0.05 and P < 0.001, respectively).
  • No significant difference in measles risk was found between vaccination before or after 9 months.
  • Infants vaccinated at 6-8 months showed similar mortality risk to those vaccinated at 9-11 months.

Conclusions:

  • Standard-titre Edmonston-Zagreb measles vaccine at 6-8 months is safe and effective.
  • Early measles vaccination is a vital preventive measure, particularly in areas with high incidence in infants under 9 months.
  • This supports timely measles immunization for improved child health outcomes.