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Updated: Jul 29, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Cyclopropyl indolequinones: mechanistic probes for bioreductive anticancer drug action
C J Moody1, C L Norton, A M Slawin
1Department of Chemistry, Loughborough University, Leicestershire, UK.
Anti-Cancer Drug Design
|October 2, 1998
Abstract:
A series of cyclopropyl indolequinones based on structures 5-7 was designed and synthesized to probe the structural features essential for bioreductive cytotoxicity. Ring opening of the cyclopropane ring under radical conditions was demonstrated to be mechanistically feasible, and related to the involvement of such one-electron processes in the cytotoxicity of cyclopropyl indolequinones under hypoxic conditions.
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