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Effect of clonidine on gastrointestinal transit time
1Texas A&M University, College of Medicine, VA Medical Center, Temple 76504, USA.
Background/Aims:
Orocecal time can be measured by lactulose H2 breath test. Duodenal entry time can be evaluated by measuring D-xylose; the duodeno-cecal time can be derived by subtracting duodenal entry time from orocecal time. In this study we established the normal value of these parameters for our laboratory in males and also evaluated the effect of clonidine on these parameters.
Methodology:
In 9 healthy male volunteers orocecal time was measured by the lactulose H2 breath test. Duodenal entry time was established by measuring blood D-xylose. Duodenocecal time was derived by subtracting duodenal entry time from orocecal time.
Results:
The mean orocecal time was 54.44 + 3.77 minutes; the mean duodenal entry time was 17.22 + 3.15 minutes and the mean duodenocecal time was 37.22 + 3.16 minutes.
Conclusions:
Oral clonidine prolonged orocecal, duodenal entry and duodenocecal times in only 33% of the subjects.