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Sequential antimicrobial therapy: pharmacokinetic and pharmacodynamic considerations in sequential therapy
1Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and University of Bristol, Westbury-on-Trym, UK.
The Journal of Infection
|November 20, 1998
Summary
Understanding sequential antimicrobial therapy is crucial. Pharmacodynamic factors like time above minimum inhibitory concentration for beta-lactams and AUC/MIC ratio for quinolones are key, but absorption impacts these, needing more research.
Area of Science:
- Pharmacology
- Microbiology
- Infectious Diseases
Background:
- Sequential antimicrobial therapy involves using multiple drugs in a specific order.
- Current research primarily focuses on initial drug exposure, neglecting subsequent effects.
Purpose of the Study:
- To investigate the largely unknown pharmacodynamic factors influencing sequential antimicrobial therapy.
- To highlight the importance of specific pharmacokinetic/pharmacodynamic (PK/PD) indices for different antibiotic classes.
Main Methods:
- The study reviews existing literature on pharmacodynamics and sequential therapy.
- It extrapolates potential PK/PD targets based on known drug classes.
Main Results:
- For beta-lactams, the time above the minimum inhibitory concentration (T>MIC) is likely crucial.
- For quinolones, the area under the concentration-time curve to minimum inhibitory concentration ratio (AUC/MIC) is predicted to be important.
Conclusions:
- Pharmacodynamic factors are critical for effective sequential antimicrobial therapy.
- Antimicrobial absorption significantly influences key PK/PD parameters, necessitating further investigation.