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Renal denervation supersensitivity revisited

T E Lohmeier1, G A Reinhart, H L Mizelle

  • 1Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA.

The American Journal of Physiology
|October 2, 1998
PubMed
Summary
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The chronically denervated kidney is not supersensitive to physiological or pathophysiological norepinephrine levels. This finding suggests renal denervation supersensitivity is unlikely to confound studies on renal nerve regulation of sodium excretion.

Area of Science:

  • Nephrology
  • Physiology
  • Pharmacology

Background:

  • Chronic renal denervation is used to study the role of renal nerves in sodium excretion.
  • Potential supersensitivity of denervated kidneys to norepinephrine (NE) could confound these studies.

Purpose of the Study:

  • To investigate if chronically denervated kidneys exhibit supersensitivity to physiological or pathophysiological plasma levels of norepinephrine (NE).

Main Methods:

  • Conscious dogs underwent unilateral renal denervation and bladder division for separate urine collection.
  • Plasma NE levels were elevated via chronic infusion (4-5 days) at varying rates.
  • Mean arterial pressure (MAP) and urinary sodium/potassium excretion ratios (Den/Inn) were monitored.

Main Results:

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  • Physiological and pathophysiological NE levels (up to ~3,000 pg/ml) did not alter MAP or Den/Inn ratios.
  • Pharmacological NE levels (~7,000 pg/ml) increased MAP and reduced Den/Inn ratios for sodium and potassium.
  • These reductions indicated lower electrolyte excretion from denervated vs. innervated kidneys at high NE levels.

Conclusions:

  • The chronically denervated kidney does not show exaggerated responses to physiological or pathophysiological circulating NE.
  • Renal denervation supersensitivity is unlikely to be a confounding factor in research on renal nerve regulation of sodium excretion.