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[Basic principles in local dermatologic therapy]

C Pflugshaupt

    Therapeutische Umschau. Revue Therapeutique
    |October 3, 1998
    PubMed
    Summary

    The vehicle in topical treatments significantly impacts drug delivery and patient quality of life. Proper vehicle selection, considering hydrophilic or lipophilic bases, is crucial for effective dermatological therapy.

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    Area of Science:

    • Dermatology and Pharmaceutical Sciences
    • Formulation science of topical drug delivery systems

    Context:

    • The vehicle or ointment base is a critical component in dermatological local treatments, influencing both therapeutic efficacy and patient quality of life.
    • Vehicles affect the epidermis through hydration, lubrication, drying, smoothness, occlusion, and protection, controlling the release, penetration, and bioavailability of active ingredients.

    Purpose:

    • To highlight the importance of vehicle selection in dermatological therapy.
    • To address the confusion caused by non-uniform vehicle designations, particularly for lipophilic emulsion systems and pastes.
    • To emphasize the need for consistent nomenclature (hydrophilic cream, lipophilic cream, ointment) and appropriate application based on skin conditions.

    Summary:

    • Vehicles significantly influence the therapeutic outcomes of topical dermatological treatments by modulating active ingredient bioavailability and affecting skin properties.
    • Lack of a uniform classification system leads to user confusion; consistent use of official designations like hydrophilic or lipophilic creams and ointments is recommended.
    • Specific vehicle types are indicated for different skin conditions: hydrophilic bases for acute lesions and seborrhoeic skin, and lipophilic systems for dry, hyperkeratotic, or sebostatic skin.

    Impact:

    • Proper vehicle selection enhances therapeutic effect and patient compliance, as cosmetic acceptance directly impacts treatment success.
    • Adverse reactions can arise from vehicle components, necessitating investigation of the vehicle if treatment is ineffective or a lesion fails to respond.
    • Standardizing vehicle terminology and understanding their specific properties are essential for optimizing topical dermatological treatments.

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