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Spermatozoa with chromosomal abnormalities may result in a higher rate of recurrent abortion
C Giorlandino1, G Calugi, L Iaconianni
1Sterility Department, Artemisia Medical Center, Rome, Italy.
Objective:
To determine whether sperm aneuploidy can lead to abortion.
Design:
Clinical study.
Setting:
Couples with reproductive problems evaluated in a private diagnostic laboratory.
Patient(S):
Two men whose wives had histories of multiple abortions.
Intervention(S):
Whole and Percoll-processed semen samples were analyzed.
Main Outcome Measure(S):
The results of fluorescence in situ hybridization.
Result(S):
Aneuploidy rates in Percoll-processed samples were higher than those found in whole specimens. Aneuploid spermatozoa also displayed greater motility.
Conclusion(S):
Sperm aneuploidy should be studied before and after Percoll capacitation in all couples with unexplained infertility.