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Treating ectopic pregnancy with the combination of mifepristone and methotrexate: a phase II nonrandomized study
M Perdu1, E Camus, P Rozenberg
1Department of Gynecology and Obstetrics, Poissy Hospital, University of Paris V, France.
Objective:
Our goal was to compare the use of a combination of methotrexate and mifepristone with methotrexate alone in the medical management of ectopic pregnancy.
Study Design:
This was a preliminary nonrandomized phase II study. All patients with progressing ectopic pregnancy meeting criteria for medical management were included. Treatment consisted of 50 mg/m2 of methotrexate injected intramuscularly and 600 mg of mifepristone, administered orally, compared with a previous group who received only 50 mg/m2 of methotrexate injected intramuscularly.
Results:
Of the 30 patients treated with the combination, there was only 1 failure, whereas medical treatment had failed for 11 of 42 patients treated with methotrexate alone.
Conclusions:
The combination of mifepristone and methotrexate decreased the risk of failure in medical treatment of ectopic pregnancy.