Related Experiment Video

Updated: Aug 26, 2026

Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

[Preventive treatment of urinary tract infections in the child]

J Gaudelus1

  • 1Service de pédiatrie, hôpital Jean-Verdier, Bondy, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|October 6, 1998
PubMed

Insights

Childhood urinary tract infections often ascend from fecal bacteria. Prophylactic treatment, including low-dose antimicrobials like nitrofurantoin, can reduce infection frequency by inhibiting bacterial attachment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Context:

  • Childhood urinary tract infections (UTIs) predominantly ascend from fecal microflora.
  • Bacterial virulence factors (adhesins, toxins) and host factors influence UTI development.
  • Recurrent UTIs or specific urinary tract abnormalities necessitate prophylactic treatment.

Purpose:

  • To review prophylactic treatment strategies for childhood urinary tract infections.
  • To discuss the efficacy and tolerance of antimicrobial agents used in prophylaxis.
  • To highlight the role of subinhibitory antimicrobial concentrations in preventing bacterial attachment.

Summary:

  • Ascending infections from fecal flora are common in children.
  • Prophylaxis is indicated for obstructed uropathy, vesicoureteral reflux, and recurrent cystitis.
  • Nitrofurantoin and cotrimoxazole are common, with subinhibitory doses (20% of curative) effectively reducing bacterial attachment and infection frequency when administered once daily.

Impact:

  • Informs clinical practice regarding UTI prophylaxis in children.
  • Suggests low-dose nitrofurantoin or cotrimoxazole as effective options for reducing UTI recurrence.
  • Emphasizes the mechanism of action of subinhibitory concentrations in preventing bacterial adherence.

More Related Videos

Establishment and Characterization of UTI and CAUTI in a Mouse Model08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

Related Concept Videos

Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...