Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Unilateral retinoblastomas with late bilateralization. Three case reports]

P Poncet1, C Levy, F Doz

  • 1Service d'Ophtalmologie, Institut Curie, Paris.

Journal Francais D'Ophtalmologie
|October 6, 1998
PubMed
Summary

Unilateral retinoblastoma can rarely affect the second eye years later, even without a family history. This highlights the importance of long-term monitoring for retinoblastoma patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Giant polycystic liver disease with thoracic involvement: An anaesthesia and surgical challenge in liver transplantation.

Revista espanola de anestesiologia y reanimacion·2026
Same author

Pathological complete response with neoadjuvant pembrolizumab and chemotherapy in non-metastatic triple-negative inflammatory breast cancer.

ESMO open·2026
Same author

<sup>18</sup>F-Fluorodeoxyglucose PET-CT evaluation after one course of neoadjuvant therapy fails to predict pCR in HER2 + BC patients: a prospective and multicentric French study.

Breast cancer research : BCR·2025
Same author

Real-world treatment patterns and effectiveness after disease progression on CDK4/6 inhibitors for HR-positive/HER2-negative metastatic breast cancer in the ESME-MBC cohort.

ESMO open·2025
Same author

First Constraint on Atmospheric Millicharged Particles with the LUX-ZEPLIN Experiment.

Physical review letters·2025
Same author

New Constraints on Cosmic Ray-Boosted Dark Matter from the LUX-ZEPLIN Experiment.

Physical review letters·2025

Area of Science:

  • Ophthalmology
  • Pediatric Oncology
  • Genetics

Background:

  • Retinoblastoma is the most common primary intraocular malignancy in children.
  • While often unilateral, bilateral retinoblastoma occurs in approximately 30-40% of cases.
  • Late bilateralization, where the second eye is affected years after the first, is exceptionally rare.

Observation:

  • This study presents three cases of unilateral retinoblastoma that subsequently developed tumors in the fellow eye.
  • Initial diagnoses were made at 3 months, 16 months, and 3 years of age.
  • Tumors in the second eye appeared at ages 16 years (one case) and 5 years (two cases).

Findings:

  • The three cases demonstrate late bilateralization of retinoblastoma, occurring years after the initial unilateral diagnosis and enucleation.

Related Experiment Videos

  • The latency period between initial diagnosis and fellow-eye tumor development varied.
  • These cases occurred in the absence of a known family history of retinoblastoma.

    • Implications:

    • The findings underscore the critical need for extended, long-term surveillance of the fellow eye in all retinoblastoma patients, irrespective of family history.
    • Prolonged monitoring may facilitate early detection of secondary tumors, potentially improving outcomes.
    • This rare presentation warrants further investigation into the underlying mechanisms of late retinoblastoma progression.