Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical approach to scleroderma

B White1

  • 1Department of Medicine, University of Maryland and the Veterans Affairs Maryland Health Care System, Baltimore, USA.

Seminars in Cutaneous Medicine and Surgery
|October 6, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adolescent cannabinoid type 1 receptor (CB1R) blockade mitigates the effects of adolescent social instability stress (SS) on socially directed behaviour in female rats.

Psychoneuroendocrinology·2026
Same author

Empathic and agentic artificial intelligence in nursing: perspectives on a human-centered framework for cancer care navigation in the United States.

ESMO real world data and digital oncology·2026
Same author

Autophagy is essential for survival and function of polyploid giant cancer cells under therapeutic stress.

Cancer letters·2026
Same author

Demonstration of a mobile optical clock ensemble at sea.

Nature communications·2025
Same author

Relative sensitivity of plastic scintillator: A comparative analysis with 60Co gamma rays, deuterium-deuterium, and deuterium-tritium neutrons.

The Review of scientific instruments·2024
Same author

Depot buprenorphine as an opioid agonist therapy in New South Wales correctional centres: a costing model.

BMC health services research·2022
Same journal

Systemic therapy for advanced cutaneous squamous cell carcinoma.

Seminars in cutaneous medicine and surgery·2019
Same journal

Atypical Fibroxanthoma.

Seminars in cutaneous medicine and surgery·2019
Same journal

Introduction, High-Risk Skin Cancer.

Seminars in cutaneous medicine and surgery·2019
Same journal

Emerging technologies for health information in dermatology: opportunities and drawbacks of web-based searches, social media, mobile applications, and direct-to-consumer genetic testing in patient care.

Seminars in cutaneous medicine and surgery·2019
Same journal

MoleMapper: an application for crowdsourcing mole images to advance melanoma early-detection research.

Seminars in cutaneous medicine and surgery·2019
Same journal

Digital imaging applications and informatics in dermatology.

Seminars in cutaneous medicine and surgery·2019
See all related articles

Systemic sclerosis (SSc) prognosis depends on early assessment of skin and organ involvement. Differentiating limited cutaneous SSc (lSSc) and diffuse cutaneous SSc (dSSc) guides treatment and predicts patient outcomes.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease characterized by heterogeneity in clinical presentation, morbidity, and mortality.
  • Early identification of disease subtype and organ involvement is crucial for predicting patient prognosis.
  • Limited cutaneous SSc (lSSc) and diffuse cutaneous SSc (dSSc) represent distinct clinical patterns with differing prognoses and potential complications.

Purpose of the Study:

  • To outline the diagnostic approach for classifying SSc subtypes (lSSc vs. dSSc).
  • To emphasize the importance of assessing early skin and internal organ involvement for prognosis.
  • To review current organ-specific treatment strategies and their impact on SSc patient outcomes.

Main Methods:

Related Experiment Videos

  • Clinical classification based on skin thickening extent (below or above elbows/knees).
  • Assessment of internal organ involvement including lungs, heart, gut, and kidneys.
  • Review of patient history, physical examinations, and laboratory findings to determine disease duration and severity.

    • Main Results:

    • Prognosis in SSc can be estimated by evaluating the extent of skin and internal organ involvement within the initial years of disease.
    • Patients with dSSc often experience a more rapid onset and potentially severe organ involvement within the first five years.
    • Significant internal organ involvement is associated with a poorer prognosis, while early treatment can mitigate morbidity.

    Conclusions:

    • Early and accurate classification of SSc subtypes and comprehensive assessment of organ involvement are vital for effective management.
    • Organ-specific treatments can reduce disease-related morbidity and potentially stabilize organ function.
    • The overall prognosis for SSc patients is improving, with a focus on early intervention and enrollment in clinical trials for novel therapies.