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Related Experiment Videos

Combined phacoemulsification and trabeculectomy versus trabeculectomy alone: a comparison study using mitomycin-C

R J Derick1, J Evans, N D Baker

  • 1Havener Eye Center, Ohio State University College of Medicine, Columbus, OH, USA.

Ophthalmic Surgery and Lasers
|October 7, 1998
PubMed
Summary

Combined phacoemulsification and trabeculectomy (PEM/TRAB) with mitomycin-C showed comparable results to trabeculectomy alone (TRAB) for glaucoma management. Both procedures effectively reduced intraocular pressure and medication needs with similar complication rates.

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Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Surgical Outcomes

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Trabeculectomy is a common surgical procedure to lower intraocular pressure (IOP).
  • Combined procedures may offer advantages in specific patient populations.

Purpose of the Study:

  • To compare the efficacy and safety of combined phacoemulsification and trabeculectomy (PEM/TRAB) plus mitomycin-C versus trabeculectomy alone (TRAB) plus mitomycin-C.
  • To evaluate intraocular pressure reduction and medication requirements post-surgery.
  • To assess complication rates and bleb survival between the two surgical techniques.

Main Methods:

  • Retrospective review of 42 eyes undergoing combined PEM/TRAB with mitomycin-C.

Related Experiment Videos

  • An age-matched control group of 42 eyes undergoing TRAB with mitomycin-C was selected.
  • All patients had a minimum follow-up of 12 months.

    • Main Results:

    • Postoperative intraocular pressure (IOP) was significantly lower in both groups at all follow-up intervals.
    • At final follow-up (mean 21.8 months), mean IOP was 13.9 mmHg for PEM/TRAB and 12.3 mmHg for TRAB.
    • Both groups required significantly fewer glaucoma medications post-surgery, with similar complication rates and excellent bleb survival.

    Conclusions:

    • Combined PEM/TRAB with mitomycin-C demonstrates comparable success rates to TRAB alone for glaucoma management.
    • The combined approach effectively reduces IOP and medication dependence.
    • Both surgical techniques are associated with similar safety profiles.