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Correlation between antigen-specific IL-2 response test and provocation test for egg allergy in atopic dermatitis
1Department of Paediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Summary
The antigen-specific interleukin-2 response (AIR) test effectively identifies egg white allergies in children. It shows high sensitivity and specificity, detecting reactions missed by other tests like RAST.
Area of Science:
- Immunology
- Allergy Diagnostics
- Pediatric Dermatology
Background:
- The antigen-specific interleukin-2 response (AIR) test aids in identifying allergy-causing antigens.
- It is valuable for assessing allergic disease activity.
Purpose of the Study:
- To investigate the correlation between the raw egg oral provocation test and the egg white antigen-specific interleukin-2 (IL-2) response test.
- To evaluate the diagnostic performance of the AIR test in children with allergic conditions.
Main Methods:
- The study involved 123 children with infantile atopic dermatitis and 13 with bronchial asthma.
- Comparison of AIR test results with raw egg oral provocation tests, IgE RAST scores, and skin-prick tests.
Main Results:
- AIR test demonstrated high sensitivity (90.4%) and specificity (84.9%) compared to provocation tests.
- AIR test detected late and delayed allergic responses, unlike RAST.
- AIR test identified positive reactions in 52% of RAST-negative patients.
Conclusions:
- The AIR test is effective for screening egg white antigens in allergic diseases.
- It can diagnose conditions missed by RAST, offering a more comprehensive allergy assessment.
- AIR test is a valuable tool for identifying relevant antigens causing allergic reactions.