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Updated: Aug 17, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Acute drug desensitization
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8859, USA.
Abstract:
Evidence is accumulating that supports a role for acute desensitization for IgE-mediated drug allergy in those patients for whom no alternative drug exists. While most of the studies have been performed in penicillin-allergic patients, this procedure has been used safely in patients with IgE sensitivity to other agents. In addition, it has been shown that modified desensitization protocols may be effective in the prevention of other immune-mediated drug reactions, as well. Thus, while much research remains to be done in this area, drug desensitization will continue to be a powerful tool in the management of drug allergy.
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