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Related Experiment Videos

Trinucleotide repeats in yeast

G F Richard1, B Dujon

  • 1Unité de Génétique moléculaire des Levures (UMR1300 CNRS and UFR927 Univ. P. M. Curie, Paris), Institut Pasteur.

Research in Microbiology
|October 10, 1998
PubMed
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Yeast genomes contain trinucleotide repeats in genes, often forming amino acid stretches. These repeats, particularly longer ones in nuclear protein genes, highlight genome instability and evolution.

Area of Science:

  • Genomics
  • Molecular Biology
  • Yeast Genetics

Background:

  • Trinucleotide repeat (TNR) arrays are present in the yeast genome.
  • These repeats occur in both protein-coding genes and intergenic regions.

Purpose of the Study:

  • To investigate the characteristics and distribution of TNRs in the yeast genome.
  • To understand the relationship between TNRs and gene function, location, and evolution.

Main Methods:

  • Bioinformatic analysis of the yeast genome sequence.
  • Identification and characterization of trinucleotide repeat arrays.
  • Comparative analysis of repeat arrays across different gene types and homologs.

Main Results:

  • TNRs in protein-coding genes are often non-random relative to the translational frame, yielding long amino acid stretches.

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  • The longest TNRs are frequently observed in genes encoding nuclear proteins.
  • Repeat frequency correlates positively with gene length but negatively with gene family membership.
  • Homologous genes often display variations in TNR length and composition, indicating instability.

    • Conclusions:

    • TNRs in yeast are non-randomly distributed and associated with specific genomic features.
    • The observed patterns suggest TNRs play a role in yeast genome evolution and protein function.
    • TNR instability in homologous genes points to dynamic evolutionary processes within gene families.