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Mutation and selection within the individual

S P Otto1, I M Hastings

  • 1Department of Zoology, University of British Columbia, Vancouver, Canada. otto@zoology.ubc.ca

Genetica
|October 10, 1998
PubMed
Summary
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Cell-lineage selection significantly impacts mutation rates and fixation probabilities, especially for rare mutations. This cellular-level selection often works with individual-level selection, favoring beneficial mutations for evolution.

Area of Science:

  • Evolutionary biology
  • Genetics
  • Cell biology

Background:

  • Selection operates at multiple levels, including cellular and individual.
  • Understanding the interplay between these levels is crucial for evolutionary insights.
  • Genetic load and mutation dynamics are fundamental concepts in population genetics.

Purpose of the Study:

  • To review literature and present new findings on cell-lineage selection's effects.
  • To quantify the impact of cell-lineage selection on mutation rates and fixation probabilities.
  • To explore the concordance and conflict between cellular and individual selection.

Main Methods:

  • Literature review on cell-lineage selection.
  • Analysis of new results concerning mutation dynamics.

Related Experiment Videos

  • Comparative analysis of selection at cellular versus individual levels.

    • Main Results:

    • Cell-lineage selection can modify mutation rates and fixation probabilities by orders of magnitude.
    • Rare recessive mutations are particularly influenced by cellular selection.
    • Mutations reaching the individual level are pre-selected for beneficial traits.

    Conclusions:

    • Cell-lineage selection plays a critical role in evolution by filtering mutations.
    • Concordance between cellular and individual selection is more common than conflict.
    • Cooperative selection at both levels favors germline selection opportunities.