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Related Experiment Videos

Prostatitis

G J Domingue1, W J Hellstrom

  • 1Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. domingue@mailhost.tcs.tulane.edu

Clinical Microbiology Reviews
|October 10, 1998
PubMed
Summary
This summary is machine-generated.

Chronic idiopathic prostatitis, often diagnosed in men, may stem from bacterial infections. Advanced molecular and culture techniques reveal bacteria, even difficult-to-culture strains, in cases previously considered abacterial, suggesting new treatment approaches.

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Area of Science:

  • Urology
  • Microbiology
  • Infectious Diseases

Background:

  • Acute bacterial prostatitis is easily diagnosed, but chronic forms, especially chronic idiopathic prostatitis (CIP), pose diagnostic challenges.
  • CIP is clinically differentiated by a lack of prostatic inflammation and "significant" leukocytes or bacteria in expressed prostatic secretions, though its etiology remains unknown.
  • While CIP is common in men, treatment is often ineffective, prompting investigation into underlying causes.

Purpose of the Study:

  • To review the spectrum of microbial causes of prostatitis, with a focus on chronic idiopathic prostatitis.
  • To explore recent evidence suggesting a bacterial etiology for CIP.
  • To discuss the implications of bacterial biofilms and difficult-to-culture organisms in treatment failures.

Main Methods:

Related Experiment Videos

  • Review of literature on acute and chronic prostatitis, including microbial causes.
  • Analysis of molecular studies detecting 16S rRNA bacterial sequences in prostate tissue.
  • Evaluation of special culture methods for identifying difficult-to-culture bacteria in expressed prostatic secretions.
  • Examination of antibiotic pharmacokinetic studies in murine models.

Main Results:

  • Molecular studies have identified 16S rRNA bacterial sequences in prostate biopsies from CIP patients negative by routine culture.
  • Specialized culture techniques have detected difficult-to-culture organisms like coryneforms and coagulase-negative staphylococci in CIP.
  • Antibiotic pharmacokinetic studies suggest treatment failures in chronic prostatitis may be due to bacterial biofilms within the prostate gland.

Conclusions:

  • Recent data strongly suggest a bacterial etiology for chronic idiopathic prostatitis.
  • The presence of difficult-to-culture bacteria and bacterial biofilms may explain treatment failures in CIP.
  • Further research into microbial causes and targeted therapies is warranted for effective CIP management.