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Management of infections due to antibiotic-resistant Streptococcus pneumoniae

S L Kaplan1, E O Mason

  • 1Section of Pediatric Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA. skaplan@bcm.tmc.edu

Clinical Microbiology Reviews
|October 10, 1998
PubMed

Insights

Antibiotic resistance in Streptococcus pneumoniae is increasing globally, necessitating updated treatment strategies. This review examines current recommendations for managing S. pneumoniae infections, particularly acute otitis media, focusing on emerging drug-resistant strains.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Increasing global prevalence of antibiotic-resistant Streptococcus pneumoniae strains.
  • Need for evolving treatment strategies for systemic S. pneumoniae infections like pneumonia and bacteremia.
  • Limited clinical efficacy data for new antibiotics against resistant S. pneumoniae isolates.

Purpose of the Study:

  • To review studies informing current treatment recommendations for S. pneumoniae infections.
  • To discuss evolving strategies for systemic infections.
  • To provide recommendations for treating acute otitis media caused by drug-resistant S. pneumoniae.

Main Methods:

  • Review of existing studies and clinical data.
  • Analysis of treatment guidelines for bacterial meningitis.
  • Evaluation of recommendations for pneumonia, bacteremia, and musculoskeletal infections.
  • Focus on otitis media treatment strategies.

Main Results:

  • Bacterial meningitis management shows consensus.
  • Treatment strategies for other infections are evolving due to new antibiotics.
  • Clinical efficacy data for new agents against resistant S. pneumoniae are limited.
  • Otitis media is the most common S. pneumoniae infection.

Conclusions:

  • Current recommendations for S. pneumoniae infections are based on reviewed studies.
  • New antibiotics show in vitro activity but limited clinical data exist.
  • Specific recommendations for acute otitis media due to drug-resistant S. pneumoniae are discussed.

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