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[Enterovirus meningoencephalitis in the last 5 years]
M Bello1, P Más Lago, R Palomera
1Instituto de Medicina Tropical Pedro Kouri.
Revista Cubana De Medicina Tropical
|January 1, 1996
Summary
Enteroviruses caused viral meningoencephalitis in a 1990-1994 study. Coxsackie A9 and Echo 30 outbreaks were identified, with Echo 6 and 11 showing higher antibody positivity.
Area of Science:
- Virology
- Epidemiology
- Clinical Microbiology
Context:
- Enteroviruses are significant causes of viral meningoencephalitis.
- A longitudinal study was conducted between 1990 and 1994 to investigate enterovirus infections.
- The study involved a large cohort of patients clinically diagnosed with meningoencephalitis.
Purpose:
- To identify enteroviruses as causative agents of viral meningoencephalitis.
- To characterize the epidemiology of enterovirus infections during the study period.
- To determine the prevalence of specific enterovirus serotypes and associated antibody responses.
Summary:
- The study analyzed 546 fecal samples, 95 cerebrospinal fluid samples, and 1,058 matched sera from 1,388 patients.
- Viral isolation was optimized using diploid cells from human fibroblasts.
- Neutralization tests identified Coxsackie A9 (1990-1991) and Echo 30 (1994) as causes of epidemic outbreaks, with Echo 6 and 11 showing higher seropositivity.
Impact:
- Highlights the role of specific enteroviruses in causing epidemic meningoencephalitis.
- Provides valuable data on enterovirus serotype distribution and antibody prevalence.
- Informs public health strategies for the prevention and control of viral meningoencephalitis.