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[Enterovirus meningoencephalitis in the last 5 years]
M Bello1, P Más Lago, R Palomera
1Instituto de Medicina Tropical Pedro Kouri.
Abstract:
The results of the study of Enterovirus as viral meningoencephalitis producing agents, carried out from 1990 to 1994, are described, 546 feces samples, 95 cerebrospinal fluids and 1,058 matched sera were studied and obtained from 1,388 patients clinically diagnosed with this disease. Samples for viral isolation were inoculated into two different cellular systems. The highest number of isolation was found in diploid cells from human fibroblast. Antibody determinations were carried out by a neutralization test (micromethod) with 11 Enterovirus antigens (Echo 4, 6, 9, 11 and 30; and Coxsackie B1, 2, 3, 4, 5 and 6) and in epidemic periods with the isolated virus. During the years under study, 2 epidemic outbreaks took place: on caused by Coxsackie A9 (1990-1991) and the other one by Echo 30 (1994). A greater positivity to Echo 6 and 11 was found among the matched sera.
Insights
Enteroviruses caused viral meningoencephalitis in a 1990-1994 study. Coxsackie A9 and Echo 30 outbreaks were identified, with Echo 6 and 11 showing higher antibody positivity.
Area of Science:
- Virology
- Epidemiology
- Clinical Microbiology
Context:
- Enteroviruses are significant causes of viral meningoencephalitis.
- A longitudinal study was conducted between 1990 and 1994 to investigate enterovirus infections.
- The study involved a large cohort of patients clinically diagnosed with meningoencephalitis.
Purpose:
- To identify enteroviruses as causative agents of viral meningoencephalitis.
- To characterize the epidemiology of enterovirus infections during the study period.
- To determine the prevalence of specific enterovirus serotypes and associated antibody responses.
Summary:
- The study analyzed 546 fecal samples, 95 cerebrospinal fluid samples, and 1,058 matched sera from 1,388 patients.
- Viral isolation was optimized using diploid cells from human fibroblasts.
- Neutralization tests identified Coxsackie A9 (1990-1991) and Echo 30 (1994) as causes of epidemic outbreaks, with Echo 6 and 11 showing higher seropositivity.
Impact:
- Highlights the role of specific enteroviruses in causing epidemic meningoencephalitis.
- Provides valuable data on enterovirus serotype distribution and antibody prevalence.
- Informs public health strategies for the prevention and control of viral meningoencephalitis.