Related Experiment Video
Updated: Aug 17, 2026

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells
Published on: December 22, 2010
HLA DR and AB surface antigens correlate with cell shape (surface area)
1Department of Pathology and Laboratory Medicine, UMD-New Jersey Medical School, Newark 07103, USA.
Abstract:
In order to help explain some of the various phenomena associated with both benign and malignant cells, this study was undertaken to determine if changes in the shape of the cell could alter the recognition of the cell. Non-transformed Human cells, HEL 299, were evaluated for their shape and surface antigens. A direct statistical correlation was found between the two surface antigens HLA AB and DR and the cell shape (surface area). The possible significance of this phenomena in non transformed human cells to neoplastic proliferation is suggested.
Related Concept Videos
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...

