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A case of infantile digital fibromatosis with spontaneous regression
M Kawaguchi1, Y Mitsuhashi, Y Hozumi
1Department of Dermatology, Yamagata University School of Medicine, Japan.
Abstract:
We reported a fourteen-month-old boy with infantile digital fibromatosis. At the age of seven months, a nodule appeared on the back of the left third toe, and developed into a slight red tumor divided into five hemispherical nodules. Histopathologically, spindle-shaped tumor cells with an eosinophilic inclusion body in the cytoplasm were seen in the dermis. Electron microscopy showed a dense body in the cytoplasm of the tumor cells. One year and two months after the first visit, the tumor regressed without any aggressive treatment. Japanese cases of infantile digital fibromatosis were reviewed. The literature review and our case suggest that the tumor should be observed without any aggressive treatment unless it causes mobile dysfunction of the affected finger or toe.
Insights
Infantile digital fibromatosis is a rare condition presenting as toe nodules. This case study shows spontaneous regression, suggesting observation without aggressive treatment is often best for this benign digital tumor.
Area of Science:
- Pediatric Dermatology
- Oncology
Background:
- Infantile digital fibromatosis (IDF) is a rare, benign soft tissue tumor affecting infants.
- It typically presents as one or more nodules on the digits of the hands or feet.
Observation:
- A fourteen-month-old boy presented with a developing tumor on his left third toe at seven months of age.
- The tumor was characterized by multiple hemispherical nodules and histopathologically showed spindle-shaped cells with eosinophilic inclusions.
- Electron microscopy revealed dense bodies within the tumor cell cytoplasm.
Findings:
- The infantile digital fibromatosis tumor spontaneously regressed over a period of one year and two months.
- Review of Japanese cases indicated a similar pattern of benign behavior and spontaneous resolution.
Implications:
- The findings suggest that infantile digital fibromatosis often follows a self-limiting course.
- Conservative management, involving observation without aggressive treatment, is recommended unless functional impairment occurs.